Keep your labels in the original packaging until you're ready for printing.
Hold your labels by the edges to prevent smudging or fingerprints.
Store your labels in a cool, dry place to avoid humidity.
Shield your labels from consistent exposure to direct sunlight or fluorescent lighting.
Separate your labels before loading them into the printer tray. Label sheets can sometimes stick together.
Make sure your label sheets are stored laying flat. This will help prevent curling or damage to the sheets prior to printing.
Design & Printing
Run each label through your printer only once. After multiple passes, you run the risk of damaging your labels and the printer.
Allow your label sheets to sit out for a short period after you receive them and before printing so they can adjust to any temperature or humidity changes.
Distinguish the facesheet of your labels from the liner side (the liner is what's discarded during the application process).
Consult your printer manual for information on specific loading and feeding instructions. Some printers feed the sheets face down, whereas others feed face up.
Stack your sheets neatly and evenly in the printer tray to help prevent feeding errors and reduce alignment issues.
Extend your design so it "bleeds" beyond the boundary of your label. You want to add an extra 0.125" to your design when possible to account for shifts during printing. Learn more about bleed.
Print a test sheet on plain printer paper before loading your labels. Stack the two sheets (test print on top) and hold them up to a light. You should be able to see if the positioning is correct.
Alignment and Scaling: Some browsers and PDF readers may scale your document, distorting the label template and your design. Download a PDF of your design and open it in Adobe Reader if possible. In the printer dialog box, make sure "Actual Size" is selected or set the scale to 100%. You may also see "Auto-Rotate and Center," make sure it is unchecked. Reprint.
Paper Jams: Print a blank sheet of printer paper. If the plain paper passes through, try printing your labels again. If your plain paper jams or comes out with streaks, you may need to clean your print rollers.
Design Outlines: If there are square outlines around elements of your design, open the advanced printer settings dialog box. Check the "Print as Image" box and reprint.